Isabella of Portugal

Isabella of Portugal (24 October 1503 – 1 May 1539) was the empress consort and queen consort of her cousin Charles V, Holy Roman Emperor, King of Spain, Archduke of Austria, and Duke of Burgundy. She was Queen of Spain and Germany, and Lady of the Netherlands from 10 March 1526 until her death in 1539, and became Holy Roman Empress and Queen of Italy in February 1530. She was the regent of Spain because of her husband's constant travels through Europe, focusing on the kingdom's policies independent of the Empire and managing the economy.